Zhao, Y;
Gilliat, AF;
Ziehm, M;
Turmaine, M;
Wang, H;
Ezcurra, M;
Yang, C;
... Gems, D; + view all
(2017)
Two forms of death in ageing Caenorhabditis elegans.
Nature Communications
, 8
, Article 15458. 10.1038/ncomms15458.
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Abstract
Ageing generates senescent pathologies, some of which cause death. Interventions that delay or prevent lethal pathologies will extend lifespan. Here we identify life-limiting pathologies in Caenorhabditis elegans with a necropsy analysis of worms that have died of old age. Our results imply the presence of multiple causes of death. Specifically, we identify two classes of corpse: early deaths with a swollen pharynx (which we call ‘P deaths’), and later deaths with an atrophied pharynx (termed ‘p deaths’). The effects of interventions on lifespan can be broken down into changes in the frequency and/or timing of either form of death. For example, glp-1 mutation only delays p death, while eat-2 mutation reduces P death. Combining pathology and mortality analysis allows mortality profiles to be deconvolved, providing biological meaning to complex survival and mortality profiles.
| Type: | Article |
|---|---|
| Title: | Two forms of death in ageing Caenorhabditis elegans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/ncomms15458 |
| Publisher version: | http://dx.doi.org/10.1038/ncomms15458 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | C.-ELEGANS, LIFE-SPAN, ISOGENIC POPULATIONS, LONGEVITY, GENETICS, MORTALITY, RATES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1559035 |
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