Chaigne, A;
Terret, M-E;
Verlhac, M-H;
(2017)
Asymmetries and Symmetries in the Mouse Oocyte and Zygote.
Results and Problems in Cell Differentiation
, 61
pp. 285-299.
10.1007/978-3-319-53150-2_13.
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Abstract
Mammalian oocytes grow periodically after puberty thanks to the dialogue with their niche in the follicle. This communication between somatic and germ cells promotes the accumulation, inside the oocyte, of maternal RNAs, proteins and other molecules that will sustain the two gamete divisions and early embryo development up to its implantation. In order to preserve their stock of maternal products, oocytes from all species divide twice minimizing the volume of their daughter cells to their own benefit. For this, they undergo asymmetric divisions in size where one main objective is to locate the division spindle with its chromosomes off-centred. In this chapter, we will review how this main objective is reached with an emphasis on the role of actin microfilaments in this process in mouse oocytes, the most studied example in mammals. This chapter is subdivided into three parts: I-General features of asymmetric divisions in mouse oocytes, II-Mechanism of chromosome positioning by actin in mouse oocytes and III-Switch from asymmetric to symmetric division at the oocyte-to-embryo transition.
| Type: | Article |
|---|---|
| Title: | Asymmetries and Symmetries in the Mouse Oocyte and Zygote |
| Location: | Germany |
| ISBN-13: | 9783319531496 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-319-53150-2_13 |
| Publisher version: | https://doi.org/10.1007/978-3-319-53150-2_13 |
| Language: | English |
| Additional information: | This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1556631 |
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