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The Landscape of Randomised Controlled Trials of Therapies in Breast Cancer in Low and Middle Income Countries

Lynch-Kelly, K; Singer, M; Williams, NR; (2017) The Landscape of Randomised Controlled Trials of Therapies in Breast Cancer in Low and Middle Income Countries. International Journal of Breast Cancer , 2017 , Article 4259704. 10.1155/2017/4259704. Green open access

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Abstract

OBJECTIVES: The objectives of this study were to identify the randomised controlled trials in breast cancer occurring in low and middle income countries (LMICs) generally and within Sub-Saharan Africa specifically, to describe the current status and identify opportunities for further research in these areas. MATERIALS AND METHODS: Data for this study were obtained from ClinicalTrials.gov. The search term “Breast Cancer Research” was used, and relevant information extracted and analysed. RESULTS: 2414 trials were identified, of which 1099 were eligible for inclusion. 69 of these trials occurred in LMICs. Of the 52 LMICs globally, 30% were participating in breast cancer research. Of the 17 LMICs in Africa, 77% are situated in Sub-Saharan Africa; 23% were participating in breast cancer research, which accounted for 9% of total Sub-Saharan African studies. CONCLUSIONS: This study provides current evidence for the need for breast cancer research in LMICs globally and within Sub-Saharan Africa. Within LMIC regions where research is active, the type and numbers of studies are unevenly distributed. High quality research within such areas should be encouraged as the results may have both local and global applications, particularly in the provision of affordable health care.

Type: Article
Title: The Landscape of Randomised Controlled Trials of Therapies in Breast Cancer in Low and Middle Income Countries
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2017/4259704
Publisher version: https://doi.org/10.1155/2017/4259704
Language: English
Additional information: Copyright © 2017 Katharine Lynch-Kelly et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/1555771
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