Mendonça, PRF;
Vargas-Caballero, M;
Erdélyi, F;
Szabó, G;
Paulsen, O;
Robinson, HPC;
(2016)
Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons.
eLife
, 5
, Article e16475. 10.7554/eLife.16475.
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Abstract
Most cortical neurons fire regularly when excited by a constant stimulus. In contrast, irregular-spiking (IS) interneurons are remarkable for the intrinsic variability of their spike timing, which can synchronize amongst IS cells via specific gap junctions. Here, we have studied the biophysical mechanisms of this irregular spiking in mice, and how IS cells fire in the context of synchronous network oscillations. Using patch-clamp recordings, artificial dynamic conductance injection, pharmacological analysis and computational modeling, we show that spike time irregularity is generated by a nonlinear dynamical interaction of voltage-dependent sodium and fast-inactivating potassium channels just below spike threshold, amplifying channel noise. This active irregularity may help IS cells synchronize with each other at gamma range frequencies, while resisting synchronization to lower input frequencies.
| Type: | Article |
|---|---|
| Title: | Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.16475 |
| Publisher version: | https://doi.org/10.7554/eLife.16475.001 |
| Language: | English |
| Additional information: | Copyright © Mendonc¸a et al. This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1554071 |
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