Z'Graggen, WJ;
Sola, R;
Graf, NE;
Serra, J;
Bostock, H;
(2017)
Sensitivity to ischaemia of single sympathetic nerve fibres innervating the dorsum of the human foot.
The Journal of Physiology
, 595
(13)
pp. 4467-4473.
10.1113/JP274324.
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Abstract
The aim of this study was to determine whether velocity recovery cycles (VRCs) could detect the effects of ischaemia on sympathetic nerve fibres. VRCs of human sympathetic nerve fibres of the superficial peroneal nerve innervating the dorsum of the foot were recorded by microneurography in 7 healthy volunteers. Sympathetic nerve fibres were identified by studying their response to manoeuvres increasing sympathetic outflow and by measuring activity-dependent slowing at 2 Hz stimulation. VRCs were assessed at rest, during 30 minutes of induced limb ischaemia and during 20 minutes of recovery after ischaemia. From each VRC was measured the relative refractory period (RRP), the supernormality and the time to peak supernormality (SN@). During ischaemia, RRP increased from the baseline value of 37.4±8.7 ms (mean ± SE) to 67.1±12.1 ms (P < 0.01) and SN@ increased from 68.6±9.8 ms to 133.8±11.0 ms (P < 0.005). The difference between SN@ and RRP separated ischaemic from non-ischaemic sympathetic nerve fibres. It is concluded that these sympathetic nerve fibres are sensitive to ischaemia, and that VRCs provide a method to study changes of axonal membrane potential of human sympathetic nerve fibres in vivo.
| Type: | Article |
|---|---|
| Title: | Sensitivity to ischaemia of single sympathetic nerve fibres innervating the dorsum of the human foot |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1113/JP274324 |
| Publisher version: | http://doi.org/10.1113/JP274324 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Sympathetic nerve fibre, ischaemia, supernormality |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1550914 |
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