Petersdorf, N;
Ross, JM;
Weiss, HA;
Barnabas, RV;
Wasserheit, JN;
Beguelin, C;
Braitstein, P;
... Sullivan, P; + view all
(2016)
Systematic review and meta-analysis of hepatitis C virus infection and HIV viral load: New insights into epidemiologic synergy.
Journal of the International AIDS Society
, 19
(1)
, Article 20944. 10.7448/IAS.19.1.20944.
Preview |
Text
Mocroft_20944-25455-1-PB.pdf - Published Version Download (751kB) | Preview |
Abstract
INTRODUCTION: Hepatitis C virus (HCV) and HIV infection frequently co-occur due to shared transmission routes. Co-infection is associated with higher HCV viral load (VL), but less is known about the effect of HCV infection on HIV VL and risk of onward transmission. METHODS: We undertook a systematic review comparing 1) HIV VL among ART-naïve, HCV co-infected individuals versus HIV mono-infected individuals and 2) HIV VL among treated versus untreated HCV co-infected individuals. We performed a random-effects meta-analysis and quantified heterogeneity using the I2 statistic. We followed Cochrane Collaboration guidelines in conducting our review and PRISMA guidelines in reporting results. RESULTS AND DISCUSSION: We screened 3925 articles and identified 17 relevant publications. A meta-analysis found no evidence of increased HIV VL associated with HCV co-infection or between HIV VL and HCV treatment with pegylated interferon-alpha-2a/b and ribavirin. CONCLUSIONS: This finding is in contrast to the substantial increases in HIV VL observed with several other systemic infections. It presents opportunities to elucidate the biological pathways that underpin epidemiological synergy in HIV co-infections and may enable prediction of which co-infections are most important to epidemic control.
| Type: | Article |
|---|---|
| Title: | Systematic review and meta-analysis of hepatitis C virus infection and HIV viral load: New insights into epidemiologic synergy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7448/IAS.19.1.20944 |
| Publisher version: | http://dx.doi.org/10.7448/IAS.19.1.20944 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 3.0 License. |
| Keywords: | Hepatitis C virus; HCV; HIV; co-infection; systematic review; viral load |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1550767 |
Archive Staff Only
 |
View Item |
