Singh, AK;
Novakova, L;
Axelsson, M;
Malmestrom, C;
Zetterberg, H;
Lycke, J;
Cardell, SL;
(2017)
High Interferon-gamma Uniquely in V delta 1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis.
Frontiers in Immunology
, 8
, Article 260. 10.3389/fimmu.2017.00260.
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Abstract
We have identified a population of T lymphocytes in peripheral blood, Vδ1 TCRγδ T lymphocytes, which unexpectedly was uniquely expressing high production of interferon-γ in newly diagnosed, untreated multiple sclerosis (MS) patients. IFN-γ production in this population distinctly correlated to parameters of clinical disease activity, inflammation, and neuronal damage. These Vδ1 T lymphocytes belong to a population of innate T lymphocytes that recognize antigen in the context of CD1d/CD1c and which include reactivity to the myelin glycosphingolipid sulfatide. Importantly, patients treated with natalizumab, blocking leukocyte transmigration to central nervous system, had completely normalized levels of interferon-γ-producing Vδ1 T lymphocytes. A biomarker and early sign of demyelinating disease in MS is much warranted and would help identify immunopathogenesis and prognosis of disease as well as monitor success with adequate treatment. The present study identifies the Vδ1 T lymphocytes as an early marker of MS and a possible link to understanding the disease etiology.
| Type: | Article |
|---|---|
| Title: | High Interferon-gamma Uniquely in V delta 1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2017.00260 |
| Publisher version: | http://doi.org/10.3389/fimmu.2017.00260 |
| Language: | English |
| Additional information: | © 2017 Singh, Novakova, Axelsson, Malmeström, Zetterberg, Lycke and Cardell. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, cerebrospinal fluid, gamma-delta T cells, interferon-gamma, multiple sclerosis, natalizumab, Vdelta1 T cells, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, FIBRILLARY ACIDIC PROTEIN, PATHOGENIC T(H)17 CELLS, CYTOKINE GM-CSF, CEREBROSPINAL-FLUID, CELIAC-DISEASE, TH17 CELLS, RESPONSES, RECEPTOR, DISTINCT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1550495 |
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