Astolfo, A;
Endrizzi, M;
Vittoria, FA;
Diemoz, PC;
Price, B;
Haig, I;
Olivo, A;
(2017)
Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy.
Scientific Reports
, 7
, Article 2187. 10.1038/s41598-017-02412-w.
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Abstract
X-ray phase contrast imaging (XPCI) is an innovative imaging technique which extends the contrast capabilities of ‘conventional’ absorption based x-ray systems. However, so far all XPCI implementations have suffered from one or more of the following limitations: low x-ray energies, small field of view (FOV) and long acquisition times. Those limitations relegated XPCI to a ‘research-only’ technique with an uncertain future in terms of large scale, high impact applications. We recently succeeded in designing, realizing and testing an XPCI system, which achieves significant steps toward simultaneously overcoming these limitations. Our system combines, for the first time, large FOV, high energy and fast scanning. Importantly, it is capable of providing high image quality at low x-ray doses, compatible with or even below those currently used in medical imaging. This extends the use of XPCI to areas which were unpractical or even inaccessible to previous XPCI solutions. We expect this will enable a long overdue translation into application fields such as security screening, industrial inspections and large FOV medical radiography – all with the inherent advantages of the XPCI multimodality.
| Type: | Article |
|---|---|
| Title: | Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-017-02412-w |
| Publisher version: | http://dx.doi.org/10.1038/s41598-017-02412-w |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, COMPUTED-TOMOGRAPHY, MAMMOGRAPHY, RADIOGRAPHY, INTERFEROMETER, RETRIEVAL, ALGORITHM, RADIATION, MICE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1549818 |
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