Vukmanovic-Stejic, M;
Sandhu, D;
Seidel, JA;
Patel, N;
Sobande, TO;
Agius, E;
Jackson, SE;
... Akbar, AN; + view all
(2015)
The Characterization of Varicella Zoster Virus Specific T Cells In Skin and Blood During Ageing.
Journal of Investigative Dermatology
, 135
(7)
pp. 1752-1762.
10.1038/jid.2015.63.
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Abstract
The varicella-zoster virus (VZV) re-activation increases during ageing. Although the effects of VZV re-activation are observed in the skin (shingles) the number or functional capacity of cutaneous VZV specific T cells have not been investigated. The numbers of circulating IFN-γ secreting VZV specific CD4+ T cells are significantly decreased in old subjects however other measures of VZV-specific CD4+ T cells, including proliferative capacity to VZV antigen stimulation and identification of VZV-specific CD4+ T cells with a MHC class II tetramer (epitope of IE-63 protein), were similar in both age groups. The majority of T cells in the skin of both age groups expressed CD69, a characteristic of skin resident T cells. VZV-specific CD4+ T cells were significantly increased in the skin compared to the blood in young and old subjects and their function was similar in both age groups. In contrast the number of Foxp3+ regulatory T cells (Tregs) and expression of the inhibitory receptor PD-1 on CD4+ T cells were significantly increased in the skin of older humans. Therefore VZV-specific CD4+ T cells in the skin of older individuals are functionally competent. However their activity may be restricted by multiple inhibitory influences in situ.
| Type: | Article |
|---|---|
| Title: | The Characterization of Varicella Zoster Virus Specific T Cells In Skin and Blood During Ageing |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/jid.2015.63 |
| Publisher version: | http://dx.doi.org/10.1038/jid.2015.63 |
| Language: | English |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1546131 |
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