Tian, X;
Zhu, Y;
Zhang, M;
Luo, L;
Wu, J;
Zhou, H;
Guan, L;
... Tian, Y; + view all
(2017)
Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy.
Chemical Communications
, 53
(23)
pp. 3303-3306.
10.1039/c6cc09470h.
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Abstract
We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(iii) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.
| Type: | Article |
|---|---|
| Title: | Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c6cc09470h |
| Publisher version: | http://doi.org/10.1039/c6cc09470h |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1544903 |
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