Wolf, D;
Bocchetta, M;
Preboske, GM;
Boccardi, M;
Grothe, MJ;
(2017)
Reference standard space hippocampus labels according to the EADC-ADNI harmonized protocol: Utility in automated volumetry.
Alzheimer's & Dementia
, 13
(8)
pp. 893-902.
10.1016/j.jalz.2017.01.009.
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Abstract
BACKGROUND: A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium–Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. METHODS: Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels. Utility of these reference labels is demonstrated in a simple atlas-based morphometry approach for automated calculation of HarP-compliant hippocampal volumes within SPM software. RESULTS: Individual tracings showed very high agreement among the five expert tracers (pairwise Jaccard indices 0.82–0.87). Automatically calculated hippocampal volumes were highly correlated (rL/R = 0.89/0.91) with gold standard volumes in the HarP benchmark data set (N = 135 MRIs), with a mean volume difference of 9% (standard deviation 7%). CONCLUSION: The consensual HarP hippocampus labels in the MNI152 template can serve as a reference standard for automated image analyses involving MNI standard space normalization.
| Type: | Article |
|---|---|
| Title: | Reference standard space hippocampus labels according to the EADC-ADNI harmonized protocol: Utility in automated volumetry |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jalz.2017.01.009 |
| Publisher version: | http://dx.doi.org/10.1016/j.jalz.2017.01.009 |
| Language: | English |
| Additional information: | © 2017 Published by Elsevier Inc. on behalf of the Alzheimer's Association. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher. |
| Keywords: | Hippocampus; Reference standard space hippocampus labels; EADC-ADNI harmonized protocol; Automated volumetry |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1543140 |
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