Bechten, A;
Wattjes, MP;
Purcell, DD;
Aliaga, ES;
Daams, M;
Brashear, HR;
Arrighi, HM;
(2017)
Validation of an MRI Rating Scale for Amyloid-Related Imaging Abnormalities.
Journal of Neuroimaging
, 27
(3)
pp. 318-325.
10.1111/jon.12422.
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Abstract
INTRODUCTION: Immunotherapeutic agents against amyloid beta (Aβ) are associated with adverse events, including amyloid-related imaging abnormalities with edema and effusion (ARIA-E). Recently, a magnetic resonance imaging (MRI) rating scale was developed for ARIA-E detection and classification. The aim of this study was to validate the use of this rating scale in a larger patient group with multiple raters. METHODS: MRI scans of 75 patients (29 with known ARIA-E and 46 control subjects) were analyzed by five neuroradiologists with different degrees of expertise, according to the ARIA-E rating scale. For each patient, we included a baseline and a follow-up fluid-attenuated inversion recovery image. Interrater agreement was calculated using intraclass correlation coefficient (ICC). RESULTS: On average, 4.1% of the ARIA-E cases were missed. We observed a high interrater agreement for scores of sulcal hyperintensity (SH; ICC = .915; 95% CI 85-95) and for the combined scores of the 2 ARIA-E findings, parenchymal hyperintensity (PH) and SH (ICC = .878; 95% CI 79-93). A slightly lower agreement for PH (ICC = .678; 95% CI 51-81) was noted. CONCLUSION: The ARIA-E rating scale is a simple tool to evaluate the extent of ARIA-E in patients recruited into Aβ-lowering therapeutic trials. It shows high interrater agreement among raters with different degrees of expertise.
| Type: | Article |
|---|---|
| Title: | Validation of an MRI Rating Scale for Amyloid-Related Imaging Abnormalities |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jon.12422 |
| Publisher version: | http://dx.doi.org/10.1111/jon.12422 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Bechten, A., Wattjes, M. P., Purcell, D. D., Aliaga, E. S., Daams, M., Brashear, H. R., Arrighi, H. M. and Barkhof, F. (2017), Validation of an MRI Rating Scale for Amyloid-Related Imaging Abnormalities. Journal of Neuroimaging. doi:10.1111/jon.12422, which has been published in final form at http://dx.doi.org/10.1111/jon.12422. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Keywords: | ARIA (amyloid-related imaging abnormalities), Alzheimer's disease (AD), MRI (magnetic resonance imaging), amyloid beta (Aβ), immunotherapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1542250 |
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