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Molecular pathology of adamantinomatous craniopharyngioma: Review and opportunities for practice

Apps, JR; Martinez-Barbera, JP; (2016) Molecular pathology of adamantinomatous craniopharyngioma: Review and opportunities for practice. Neurosurgical Focus , 41 (6) , Article E4. 10.3171/2016.8.FOCUS16307. Green open access

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Abstract

Since the first identification of CTNNB1 mutations in adamantinomatous craniopharyngioma (ACP), much has been learned about the molecular pathways and processes that are disrupted in ACP pathogenesis. To date this understanding has not translated into tangible patient benefit. The recent development of novel techniques and a range of preclinical models now provides an opportunity to begin to support treatment decisions and develop new therapeutics based on molecular pathology. In this review the authors summarize many of the key findings and pathways implicated in ACP pathogenesis and discuss the challenges that need to be tackled to translate these basic science findings for the benefit of patients.

Type: Article
Title: Molecular pathology of adamantinomatous craniopharyngioma: Review and opportunities for practice
Open access status: An open access version is available from UCL Discovery
DOI: 10.3171/2016.8.FOCUS16307
Publisher version: http://dx.doi.org/10.3171/2016.8.FOCUS16307
Language: English
Additional information: © AANS, 2016.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1541657
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