Apps, JR;
Martinez-Barbera, JP;
(2016)
Molecular pathology of adamantinomatous craniopharyngioma: Review and opportunities for practice.
Neurosurgical Focus
, 41
(6)
, Article E4. 10.3171/2016.8.FOCUS16307.
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Abstract
Since the first identification of CTNNB1 mutations in adamantinomatous craniopharyngioma (ACP), much has been learned about the molecular pathways and processes that are disrupted in ACP pathogenesis. To date this understanding has not translated into tangible patient benefit. The recent development of novel techniques and a range of preclinical models now provides an opportunity to begin to support treatment decisions and develop new therapeutics based on molecular pathology. In this review the authors summarize many of the key findings and pathways implicated in ACP pathogenesis and discuss the challenges that need to be tackled to translate these basic science findings for the benefit of patients.
| Type: | Article |
|---|---|
| Title: | Molecular pathology of adamantinomatous craniopharyngioma: Review and opportunities for practice |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3171/2016.8.FOCUS16307 |
| Publisher version: | http://dx.doi.org/10.3171/2016.8.FOCUS16307 |
| Language: | English |
| Additional information: | © AANS, 2016. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1541657 |
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