Bryant, VA;
Booth, J;
Palm, L;
Ashworth, M;
Jacques, TS;
Sebire, NJ;
(2017)
Childhood neoplasms presenting at autopsy: A 20-year experience.
Pediatric Blood & Cancer
, 64
(9)
, Article e26474. 10.1002/pbc.26474.
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Abstract
OBJECTIVE: The aims of the review are to establish the number of undiagnosed neoplasms presenting at autopsy in a single centre and to determine the incidence and most common causes of sudden unexpected death due to neoplasia in infancy and childhood (SUDNIC). DESIGN: Retrospective observational study of paediatric autopsies performed on behalf of Her Majesty's Coroner over a 20-year period (1996-2015; n = 2,432). Neoplasms first diagnosed at autopsy were identified from an established database and cases meeting the criteria for sudden unexpected death were further categorised. RESULTS: Thirteen previously undiagnosed neoplasms were identified, including five haematological malignancies, two medulloblastomas, two neuroblastomas, two cardiac tumours and two malignancies of renal origin. Eight cases met the criteria for SUDNIC (0.33% of autopsies), the commonest group of which were haematological malignancies (n = 3). CONCLUSIONS: Neoplasms presenting as unexpected death in infancy and childhood and diagnosed at autopsy are rare. The findings suggest that haematological malignancies are the commonest cause of SUDNIC and highlight the importance of specialist autopsy in cases of sudden unexpected death.
| Type: | Article |
|---|---|
| Title: | Childhood neoplasms presenting at autopsy: A 20-year experience |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/pbc.26474 |
| Publisher version: | http://dx.doi.org/10.1002/pbc.26474 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Bryant, VA; Booth, J; Palm, L; Ashworth, M; Jacques, TS; Sebire, NJ; (2017) Childhood neoplasms presenting at autopsy: A 20-year experience. Pediatric Blood & Cancer (In press), which has been published in final form at 10.1002/pbc.26474. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Keywords: | Autopsy, childhood, infant, neoplasm, sudden unexpected death |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1541604 |
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