Russ, TC;
Hannah, J;
Batty, GD;
Booth, CC;
Deary, IJ;
Starr, JM;
(2017)
Childhood cognitive ability and incident dementia: the 1932 Scottish Mental Survey cohort into their tenth decade.
Epidemiology
, 28
(3)
pp. 361-364.
10.1097/EDE.0000000000000626.
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Abstract
BACKGROUND: The prevention of dementia is a global priority but its etiology is poorly understood. Early life cognitive ability has been linked to subsequent dementia risk but studies to date have been small and none has examined sex differences. METHODS: In the 1932 Scottish Mental Survey cohort, we related intelligence test scores at age 11 years in 16,370 boys and 16,097 girls (born in 1921) to incident dementia aged ≥65 years as ascertained using probabilistic linkage to electronic health records up to the age of 92 years (1231 cases in men, 2163 in women; median follow up 15 years). RESULTS: Compared to the highest intelligence group (≥115), dementia risk was raised in the lowest-scoring category (<85) and these associations were stronger for women (hazard ratio; 95% confidence interval: 1.51, 1.29 to 1.76) than men (1.19, 0.98 to 1.44; P-value for interaction by gender: 0.054). There was evidence of a dose-response association between childhood IQ and dementia in women (IQ 100-114.9 compared to ≥115: 1.18, 1.03 to 1.34; IQ 85-99.9: 1.32, 1.15 to 1.51; P-value for trend<0.001) but not in men (1.05, 0.89 to 1.24; 1.01, 0.85 to 1.21; 0.44) CONCLUSIONS:: Childhood intelligence is related to subsequent dementia risk but this association is not the same in men and women.
| Type: | Article |
|---|---|
| Title: | Childhood cognitive ability and incident dementia: the 1932 Scottish Mental Survey cohort into their tenth decade |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/EDE.0000000000000626 |
| Publisher version: | http://doi.org/10.1097/EDE.0000000000000626 |
| Language: | English |
| Additional information: | Copyright © 2017. This manuscript version is published under a Creative Commons Attribution Non-commercial 4.0 International licence (CC BY-NC 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Dementia, cognitive ability, cohort study, survival analysis, life course epidemiology, risk factors, dementia prevention |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1541251 |
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