Keller, AJ;
Houlton, R;
Kampa, BM;
Lesica, NA;
Mrsic-Flogel, TD;
Keller, GB;
Helmchen, F;
(2017)
Stimulus relevance modulates contrast adaptation in visual cortex.
eLife
, 6
, Article e21589. 10.7554/eLife.21589.
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Abstract
A general principle of sensory processing is that neurons adapt to sustained stimuli by reducing their response over time. Most of our knowledge on adaptation in single cells is based on experiments in anesthetized animals. How responses adapt in awake animals, when stimuli may be behaviorally relevant or not, remains unclear. Here we show that contrast adaptation in mouse primary visual cortex depends on the behavioral relevance of the stimulus. Cells that adapted to contrast under anesthesia maintained or even increased their activity in awake naïve mice. When engaged in a visually guided task, contrast adaptation re-occurred for stimuli that were irrelevant for solving the task. However, contrast adaptation was reversed when stimuli acquired behavioral relevance. Regulation of cortical adaptation by task demand may allow dynamic control of sensory-evoked signal flow in the neocortex.
| Type: | Article |
|---|---|
| Title: | Stimulus relevance modulates contrast adaptation in visual cortex |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.21589 |
| Publisher version: | http://doi.org/10.7554/eLife.21589 |
| Language: | English |
| Additional information: | Copyright © Keller et al.2017 This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| Keywords: | attentional modulation, behavior, contrast adaptation, mouse, neuroscience, sensory processing, stimulus relevance, visual attention |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1540821 |
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