Yap, L-W;
Brok, J;
Pritchard-Jones, K;
(2017)
Role of CD56 in Normal Kidney Development and Wilms Tumorigenesis.
Fetal and Pediatric Pathology
, 36
(1)
pp. 62-75.
10.1080/15513815.2016.1256358.
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Abstract
The cell-surface glycoprotein CD56 has three major isoforms that play important roles in cell adhesion and signaling, which may promote cell proliferation, differentiation, survival, or migration. It is an important molecule in normal kidney development and acts as a key marker in Wilms tumor stem and progenitor cells. Here, we review the structural and genetic features of the CD56 glycoprotein, and summarize its roles in the normal versus diseased metanephric blastema. We discuss areas of CD56-related research that may complement or improve existing Wilms tumor treatment strategies, including the antibody-drug conjugate lorvotuzumab mertansine that binds to CD56.
| Type: | Article |
|---|---|
| Title: | Role of CD56 in Normal Kidney Development and Wilms Tumorigenesis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/15513815.2016.1256358 |
| Publisher version: | http://dx.doi.org/10.1080/15513815.2016.1256358 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | CD56, NCAM-1, Kidney development, Wilms tumor, Blastema, Lorvotuzumab mertansine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1540602 |
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