Mattsson, N;
Insel, PS;
Palmqvist, S;
Portelius, E;
Zetterberg, H;
Weiner, M;
Blennow, K;
(2016)
Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease.
EMBO Molecular Medicine
, 8
(10)
pp. 1184-1196.
10.15252/emmm.201606540.
Preview |
Text
Zetterberg_1184.full.pdf - Published Version Download (1MB) | Preview |
Abstract
Cerebrospinal fluid (CSF) tau (total tau, T‐tau), neurofilament light (NFL), and neurogranin (Ng) are potential biomarkers for neurodegeneration in Alzheimer's disease (AD). It is unknown whether these biomarkers provide similar or complementary information in AD. We examined 93 patients with AD, 187 patients with mild cognitive impairment, and 109 controls. T‐tau, Ng, and NFL were all predictors of AD diagnosis. Combinations improved the diagnostic accuracy (AUC 85.5% for T‐tau, Ng, and NFL) compared to individual biomarkers (T‐tau 80.8%; Ng 71.4%; NFL 77.7%). T‐tau and Ng were highly correlated (ρ = 0.79, P < 0.001) and strongly associated with β‐amyloid (Aβ) pathology, and with longitudinal deterioration in cognition and brain structure, primarily in people with Aβ pathology. NFL on the other hand was not associated with Aβ pathology and was associated with cognitive decline and brain atrophy independent of Aβ. T‐tau, Ng, and NFL provide partly independent information about neuronal injury and may be combined to improve the diagnostic accuracy for AD. T‐tau and Ng reflect Aβ‐dependent neurodegeneration, while NFL reflects neurodegeneration independently of Aβ pathology.
| Type: | Article |
|---|---|
| Title: | Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.15252/emmm.201606540 |
| Publisher version: | http://dx.doi.org/10.15252/emmm.201606540 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Alzheimer's, biomarker, CSF, neurodegeneration, mild cognitive impairment, beta-amyloid pathology, association workgroups, diagnostic guidelines, national institute, protein-levels, frontotemporal dementia, recommendations, biomarkers |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1538318 |
Archive Staff Only
 |
View Item |
