Pomara, N;
Bruno, D;
Osorio, RS;
Reichert, C;
Nierenberg, J;
Sarreal, AS;
Hernando, RT;
... Blennow, K; + view all
(2016)
State-dependent alterations in cerebrospinal fluid A42 levels in cognitively intact elderly with late-life major depression.
NeuroReport
, 27
(14)
pp. 1068-1071.
10.1097/WNR.0000000000000658.
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Abstract
Depression has been linked to Alzheimer’s disease as either an increased risk factor for its development or as a prodromal symptom. The neurobiological basis for such an association, however, remains poorly understood. Numerous studies have examined whether changes in amyloid beta (A[beta]) metabolism, which are implicated in the pathogenesis of Alzheimer’s disease, are also found in depression. In this paper, we investigated the relationship between depressive symptoms and cerebrospinal fluid (CSF) A[beta] indices in otherwise healthy, cognitively normal elderly with late-life major depression (LLMD) and controls using a longitudinal approach, which is a novel contribution toward the literature. Significantly lower levels of CSF A[beta]42 were observed in the LLMD group at baseline and were associated with more severe depressive symptoms. During longitudinal follow-up, the depressed group remained cognitively unchanged, but was significantly less depressed than at baseline. A greater improvement in depressive symptoms was associated with increases in CSF A[beta]42 levels in both groups. Increases in CSF A[beta]42 and A[beta]40 were also associated with increased CSF total-tau levels. Our results suggest that LLMD may be associated with state-dependent effects of CSF A[beta]42 levels. Future studies should determine whether the association reflects state-dependent changes in neuronal activity and/or brain amyloid burden in depression.
| Type: | Article |
|---|---|
| Title: | State-dependent alterations in cerebrospinal fluid A42 levels in cognitively intact elderly with late-life major depression |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/WNR.0000000000000658 |
| Publisher version: | http://dx.doi.org/10.1097/WNR.0000000000000658 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, A42, Alzheimer's Disease, Elderly, Late-Life Major Depression, Default-Mode Network, Amyloid-Beta, Alzheimers-Disease, Neuronal-Activity, Risk-Factor, Dementia, Individuals, Connectivity, Association, Impairment |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1538252 |
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