Yang, Y;
Tullberg, M;
Mehlig, K;
Rosengren, A;
Toren, K;
Zetterberg, H;
Wikkelso, C;
(2016)
The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus.
PLOS One
, 11
(7)
, Article e0158985. 10.1371/journal.pone.0158985.
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Abstract
Introduction: Amyloid plaque has been reported in brain biopsies from patients with idiopathic normal-pressure hydrocephalus (iNPH) and proposed as a significant feature of the pathophysiology. Presence of the apolipoprotein E ε4 (APOE ε4) allele is associated with increased risk of Alzheimer’s disease (AD). / Aims: To compare the distribution of APOE genotype in iNPH patients with an age-matched population-based control group and with Alzheimer’s disease (AD) patients. / Methods: APOE genotype frequencies were determined in 77 iNPH patients (50 men and 27 women, mean age 71.7 years) diagnosed with iNPH, a sample of 691 AD patients and 638 age-matched population controls (299 men and 339 women) from the INTERGENE cohort. / Results: The APOE distribution did not differ significantly between the iNPH patients and the control population. The per e4-allele odds-ratio (OR) of iNPH was given by OR = 0.90, 95% confidence interval (CI) = (0.50, 1.60) that was considerably smaller than the per-allele OR of AD, OR = 5.34 (4.10, 7.00). / Conclusion: The results suggest that the APOE-related risk of AD in patients with iNPH is not higher than in the general population.
| Type: | Article |
|---|---|
| Title: | The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0158985 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0158985 |
| Language: | English |
| Additional information: | Copyright © 2016 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Alzheimer disease, Biopsy, Variant genotypes, Cerebrospinal fluid, Hydrocephalus, Diagnostic medicine, Amyloid plaques, Pathology and laboratory medicine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1537470 |
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