Skoog, I;
Horder, H;
Frandin, K;
Johansson, L;
Ostling, S;
Blennow, K;
Zetterberg, H;
(2016)
Association between APOE Genotype and Change in Physical Function in a Population-Based Swedish Cohort of Older Individuals Followed Over Four Years.
Frontiers in Aging Neuroscience
, 8
, Article 225. 10.3389/fnagi.2016.00225.
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Abstract
The association between decline in physical function and age-related conditions, such as reduced cognitive performance and vascular disease, may be explained by genetic influence on shared biological pathways of importance for aging. The apolipoprotein E (APOE) gene is well-known for its association with Alzheimer’s disease, but has also been related to other disorders of importance for aging. The aim of this study was to investigate possible associations between APOE allele status and physical function in a population-based longitudinal study of older individuals. In 2005, at the age of 75, 622 individuals underwent neuropsychiatric and physical examinations, including tests of physical function, and APOE-genotyping. Follow-up examinations were performed at age 79. A significantly larger decline in grip strength (p = 0.015) between age 75 and 79 was found when comparing APOE ε4 allele carriers with non-carriers [10.3 (±10.8) kg versus 7.8 (±10.1) kg]. No association was seen with decline in gait speed, chair-stand, or balance. The association with grip strength remained after correction for cognitive and educational level, depression, cardiovascular disease, stroke, and BMI.
| Type: | Article |
|---|---|
| Title: | Association between APOE Genotype and Change in Physical Function in a Population-Based Swedish Cohort of Older Individuals Followed Over Four Years |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnagi.2016.00225 |
| Publisher version: | http://doi.org/10.3389/fnagi.2016.00225 |
| Language: | English |
| Additional information: | Copyright © 2016 Skoog, Hörder, Frändin, Johansson, Östling, Blennow, Zetterberg and Zettergren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Geriatrics & Gerontology, Neurosciences, Neurosciences & Neurology, physical function, grip strength, gait speed, APOE epsilon 4 allele, dementia, APOLIPOPROTEIN-E POLYMORPHISM, ALZHEIMERS-DISEASE, COGNITIVE DECLINE, GRIP STRENGTH, ALLELE, ADULTS, RISK, WOMEN, PERFORMANCE, PREVALENCE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1537441 |
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