Zumla, A;
Maeurer, M;
(2016)
Host-directed therapies for multidrug resistant tuberculosis.
International Journal of Mycobacteriology
, 5
(S1)
S21-S22.
10.1016/j.ijmyco.2016.09.044.
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Abstract
Tuberculosis (TB) causes 1.3 million deaths annually. There are 0.5 million cases of multidrug resistant TB (MDR-TB) and the number of cases is rising globally. The current status quo of the lengthy treatment duration and poor treatment outcomes associated with MDR/extensively drug-resistant TB, and those with comorbidity of TB with human immunodeficiency virus and noncommunicable diseases in sub-Saharan Africa is unacceptable. The TB drug pipeline remains sparse. New innovations for shortening the duration of therapy and improving treatment outcomes (cure and long-term functional disability due to lung damage) are urgently required. A wide range of host-directed therapies (HDT) are now available which require evaluation as adjuncts to current TB drug treatment.
| Type: | Article |
|---|---|
| Title: | Host-directed therapies for multidrug resistant tuberculosis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijmyco.2016.09.044 |
| Publisher version: | http://dx.doi.org/10.1016/j.ijmyco.2016.09.044 |
| Language: | English |
| Additional information: | © 2016 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Host-directed therapy; MDR-TB; Tuberculosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1536730 |
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