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Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline

Verfaillie, SC; Tijms, B; Versteeg, A; Benedictus, MR; Bouwman, FH; Scheltens, P; Barkhof, F; ... van der Flier, WM; + view all (2016) Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring , 5 pp. 43-52. 10.1016/j.dadm.2016.10.007. Green open access

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Abstract

INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD). METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia. RESULTS: After a follow-up of the mean (standard deviation) 3 (2) years, 49 patients (16%) showed clinical progression to MCI (n = 32), AD (n = 9), or non-AD dementia (n = 8). Hippocampal volumes, thinner cortex of the AD-signature (hazard ratio [95% confidence interval], 5 [2-17]) and various AD-signature subcomponents were associated with increased risk of clinical progression. Stratified analyses showed that thinner AD-signature cortex was specifically predictive for clinical progression to dementia but not to MCI. DISCUSSION: In SCD patients, thinner regional cortex is associated with clinical progression to dementia.

Type: Article
Title: Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dadm.2016.10.007
Publisher version: http://doi.org/10.1016/j.dadm.2016.10.007
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Alzheimer's disease cortical signature, Cognitive complaint, Cognitively normal, Cortical thickness, Dementia, MCI, MRI, Subjective cognitive decline
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/1535636
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