Kent, NW;
Blunn, G;
Karpukhina, N;
Davis, G;
de Godoy, RF;
Wilson, RM;
Coathup, M;
... Hill, R; + view all
(2016)
In vitro and in vivo study of commercial calcium phosphate cement HydroSet™.
Journal of Biomedical Materials Research: Part B Applied Biomaterials
, 106
(1)
pp. 21-30.
10.1002/jbm.b.33809.
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Abstract
The commercial calcium phosphate cement, HydroSet™, was investigated in vitro, studying phase formation, compressive strength and setting time, followed by an ovine in vivo study to measure osseointegration, bone apposition and bone-to-graft contact. The X-ray diffraction and 31P Magic Angle Spinning Nuclear Magnetic Resonance (MAS NMR) results showed the initial formation of octacalcium phosphate and hydroxyapatite at one hour. Over 7 days the octacalcium phosphate transformed to apatite, which was the only crystalline phase of the cement at 28 days. This apatite phase is thought to be a calcium deficient apatite. In the scanning electron microscopy, histological images of 12-week ovine in vivo results showed a high degree of osseointegration, 92.5%. Compressive strength comparisons between in vitro and in vivo measurements showed a dramatic difference between the in vitro measurements (highest 25.4 MPa) and in vivo (95 MPa), attributed to bone ingrowth into the cement in vivo. To the best of our knowledge this is the first time phase evolution of HydroSet™ and the properties studied in vitro complement the in vivo evaluation of the cement in a publication. The significance of the new finding of initial formation of octacalcium phosphate in this cement is discussed.
| Type: | Article |
|---|---|
| Title: | In vitro and in vivo study of commercial calcium phosphate cement HydroSet™ |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/jbm.b.33809 |
| Publisher version: | http://dx.doi.org/10.1002/jbm.b.33809 |
| Language: | English |
| Additional information: | © 2016 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Kent, NW; Blunn, G; Karpukhina, N; Davis, G; de Godoy, RF; Wilson, RM; Coathup, M; (2016) In vitro and in vivo study of commercial calcium phosphate cement HydroSet™. Journal of Biomedical Materials Research: Part B Applied Biomaterials (In press), which has been published in final form at 10.1002/jbm.b.33809. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1534004 |
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