Leyhe, T;
Reynolds, CF;
Melcher, T;
Linnemann, C;
Kloeppel, S;
Blennow, K;
Zetterberg, H;
... Hampel, H; + view all
(2017)
A common challenge in older adults: Classification, overlap, and therapy of depression and dementia.
Alzheimer's & Dementia
, 13
(1)
pp. 59-71.
10.1016/j.jalz.2016.08.007.
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Abstract
Late-life depression is frequently associated with cognitive impairment. Depressive symptoms are often associated with or even precede a dementia syndrome. Moreover, depressive disorders increase the risk of persistence for mild cognitive impairment and dementia. Here, we present both the current state of evidence and future perspectives regarding the integration and value of clinical assessments, neuropsychological, neurochemical, and neuroimaging biomarkers for the etiological classification of the dementia versus the depression syndrome and for the prognosis of depression relating to dementia risk. Finally, we summarize the existing evidence for both pharmacotherapy and psychotherapy of depression in demented patients. There is an urgent need for large-scale collaborative research to elucidate the role and interplay of clinical and biological features in elderly individuals with depressive disorders who are at elevated risk for developing dementia. To overcome barriers for successful drug development, we propose the introduction of the precision medicine paradigm to this research field.
| Type: | Article |
|---|---|
| Title: | A common challenge in older adults: Classification, overlap, and therapy of depression and dementia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jalz.2016.08.007 |
| Publisher version: | http://doi.org/10.1016/j.jalz.2016.08.007 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, Depression, Dementia, Differential Diagnosis, Classification, Prognosis, Biomarkers, Neuroimaging, Pharmacotherapy, Psychological Intervention, Precision Medicine, Late-Life Depression, Mild Cognitive Impairment, Provisional Diagnostic-Criteria, Spectrometry-Based Proteomics, Defined Vascular Depression, Alzheimers-Disease, Geriatric Depression, Double-Blind, Major Depression, Clinical-Trial |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1533721 |
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