Puoti, M;
Lorenzini, P;
Cozzi-Lepri, A;
Gori, A;
Mastroianni, C;
Rizzardini, G;
Mazzarello, G;
... Icona Foundation Study Group, .; + view all
(2017)
Incidence and Progression to Cirrhosis of New HCV infections in Persons Living with HIV.
Clinical Microbiology and Infection
, 23
(4)
267.e1-267.e4.
10.1016/j.cmi.2016.12.003.
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Abstract
OBJECTIVE: To estimate the incidence of HCV seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with HIV. METHODS: We analyzed data on 4,059 persons with HIV enrolled in a cohort study in Italy. RESULTS: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion. CONCLUSIONS: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.
| Type: | Article |
|---|---|
| Title: | Incidence and Progression to Cirrhosis of New HCV infections in Persons Living with HIV. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cmi.2016.12.003 |
| Publisher version: | http://dx.doi.org/10.1016/j.cmi.2016.12.003 |
| Language: | English |
| Additional information: | © 2016. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | HIV, cirrhosis, cohort study, hepatitis C virus, incidence |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1533199 |
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