Pakzad-Vaezi, K;
Keane, P;
Cardoso, JN;
Egan, C;
Tufail, A;
(2017)
Optical coherence tomography angiography of foveal hypoplasia.
British Journal of Ophthalmology
, 101
(7)
pp. 985-988.
10.1136/bjophthalmol-2016-309200.
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Abstract
AIMS: To discuss foveal development in the context of detailed retinal vasculature imaging in foveal hypoplasia using optical coherence tomography angiography. METHODS: In this case series, the optical coherence tomography angiography results of four patients with idiopathic foveal hypoplasia and two patients with foveal hypoplasia secondary to oculocutaneous albinism are presented. RESULTS: Cases with intact visual acuity demonstrated lower grades of foveal hypoplasia on optical coherence tomography, while those with poor vision demonstrated high grades of foveal hypoplasia. The superficial retinal capillary plexus was intact in the foveal area in all cases, with no demonstrable foveal avascular zone. The deep retinal capillary plexus was absent to variable degrees in most cases, but was most persistent in those cases with reduced vision. CONCLUSIONS: The superficial retinal capillary plexus is present in cases with foveal hypoplasia, while the deep retinal capillary plexus is absent to varying degrees. Our findings support the hypothesis that an intact foveal avascular zone of the deep capillary plexus allows for outer retinal photoreceptor specialisation to occur unimpeded, resulting in preserved visual acuity, while this process may be inhibited by an absent deep capillary foveal avascular zone with resultant poor vision.
| Type: | Article |
|---|---|
| Title: | Optical coherence tomography angiography of foveal hypoplasia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/bjophthalmol-2016-309200 |
| Publisher version: | http://dx.doi.org/10.1136/bjophthalmol-2016-309200 |
| Language: | English |
| Additional information: | Copyright © 2016 by the BMJ Publishing Group Ltd. All rights reserved. The final publication is available at Br J Ophthalmol via http://dx.doi.org/10.1136/bjophthalmol-2016-309200 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1531630 |
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