Dufek, S;
Booth, C;
Carroll, A;
van’t Hoff, W;
Kleta, R;
Bockenhauer, D;
(2017)
Urea is successful in treating inappropriate antidiuretic hormone secretion in an infant.
Acta Paediatrica
, 106
(3)
pp. 513-515.
10.1111/apa.13697.
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Abstract
The syndrome of inappropriate antidiuretic hormone (SIADH) consists of a number of key features, namely hyponatraemia, inappropriate urinary concentration and clinical euvolaemia or hypervolaemia. It is caused by inappropriate secretion of the antidiuretic hormone (ADH), which activates the vasopressin type 2 receptor (AVPR2) in the principal cells of the collecting duct of the kidney and leads to increased reabsorption of water through aquaporin 2 channels. Common causes of SIADH in children include trauma, asphyxia, pain, stress, certain drugs and recent neurosurgery (1).
| Type: | Article |
|---|---|
| Title: | Urea is successful in treating inappropriate antidiuretic hormone secretion in an infant |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/apa.13697 |
| Publisher version: | http://dx.doi.org/10.1111/apa.13697 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1530995 |
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