Peterson, I;
Bar-Zeev, N;
Kennedy, N;
Ho, A;
Newberry, L;
SanJoaquin, MA;
Menyere, M;
... Heyderman, RS; + view all
(2016)
Respiratory Virus–Associated Severe Acute Respiratory Illness and Viral Clustering in Malawian Children in a Setting With a High Prevalence of HIV Infection, Malaria, and Malnutrition.
Journal of Infectious Diseases
, 214
(11)
pp. 1700-1711.
10.1093/infdis/jiw426.
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Abstract
BACKGROUND: We used data from 4 years of pediatric severe acute respiratory illness (SARI) sentinel surveillance in Blantyre, Malawi, to identify factors associated with clinical severity and coviral clustering. METHODS: From January 2011 to December 2014, 2363 children aged 3 months to 14 years presenting to the hospital with SARI were enrolled. Nasopharyngeal aspirates were tested for influenza virus and other respiratory viruses. We assessed risk factors for clinical severity and conducted clustering analysis to identify viral clusters in children with viral codetection. RESULTS: Hospital-attended influenza virus–positive SARI incidence was 2.0 cases per 10 000 children annually; it was highest among children aged <1 year (6.3 cases per 10 000), and human immunodeficiency virus (HIV)–infected children aged 5–9 years (6.0 cases per 10 000). A total of 605 SARI cases (26.8%) had warning signs, which were positively associated with HIV infection (adjusted risk ratio [aRR], 2.4; 95% confidence interval [CI], 1.4–3.9), respiratory syncytial virus infection (aRR, 1.9; 95% CI, 1.3–3.0) and rainy season (aRR, 2.4; 95% CI, 1.6–3.8). We identified 6 coviral clusters; 1 cluster was associated with SARI with warning signs. CONCLUSIONS: Influenza vaccination may benefit young children and HIV-infected children in this setting. Viral clustering may be associated with SARI severity; its assessment should be included in routine SARI surveillance.
| Type: | Article |
|---|---|
| Title: | Respiratory Virus–Associated Severe Acute Respiratory Illness and Viral Clustering in Malawian Children in a Setting With a High Prevalence of HIV Infection, Malaria, and Malnutrition |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/infdis/jiw426 |
| Publisher version: | http://dx.doi.org/10.1093/infdis/jiw426 |
| Language: | English |
| Additional information: | This is a pre-copyedited, author-produced PDF of an article accepted for publication in Journal of Infectious Diseases following peer review. The version of record Ingrid Peterson, Naor Bar-Zeev, Neil Kennedy, Antonia Ho, Laura Newberry, Miguel A. SanJoaquin, Mavis Menyere, Maaike Alaerts, Gugulethu Mapurisa, Moses Chilombe, Ivan Mambule, David G. Lalloo, Suzanne T. Anderson, Thembi Katangwe, Nigel Cunliffe, Nico Nagelkerke, Meredith McMorrow, Marc-Allain Widdowson, Neil French, Dean Everett, and Robert S. Heyderman: Respiratory Virus–Associated Severe Acute Respiratory Illness and Viral Clustering in Malawian Children in a Setting With a High Prevalence of HIV Infection, Malaria, and Malnutrition J Infect Dis. (2016) 214 (11): 1700-1711. is available online at: http://dx.doi.org/10.1093/infdis/jiw426. |
| Keywords: | Children, SARI, Africa, viral coinfection, influenza, |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1530848 |
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