Wall, EC;
Gritzfeld, JF;
Scarborough, M;
Ajdukiewicz, KMB;
Mukaka, M;
Corless, C;
Lalloo, DG;
(2014)
Genomic pneumococcal load and CSF cytokines are not related to outcome in Malawian adults with meningitis.
Journal of Infection
, 69
(5)
pp. 440-446.
10.1016/j.jinf.2014.06.011.
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Abstract
OBJECTIVE: Bacterial meningitis in sub-Saharan Africa is predominantly caused by Streptococcus pneumoniae, is often associated with HIV co-infection and mortality rates are double those seen in better resourced settings. METHODS: To investigate the cause of this excessive mortality we quantified the pneumococcal DNA load and six common pro-inflammatory cytokines in the cerebrospinal fluid (CSF) of Malawian adults with culture proven pneumococcal meningitis and correlated the results to clinical parameters and outcome. There are currently no published data relating bacterial load to outcome in adults with pneumococcal meningitis. RESULTS: The mean age of patients was 32 years, 82% were HIV infected and 49% had died by day 40. CSF bacterial loads were high (median 6.5 × 105 copies/ml CSF) and there was no significant variation in bacterial load between survivors and non-survivors. All pro-inflammatory CSF cytokines were elevated in the CSF, with no clinically important differences between survivors and non-survivors. HIV status did not affect the CSF bacterial load or cytokine response. CONCLUSION: Mortality from pneumococcal meningitis in adults in sub-Saharan Africa is not related to pneumococcal bacterial load. More research is needed to understand the very high mortality from meningitis in this region.
| Type: | Article |
|---|---|
| Title: | Genomic pneumococcal load and CSF cytokines are not related to outcome in Malawian adults with meningitis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jinf.2014.06.011 |
| Publisher version: | http://dx.doi.org/10.1016/j.jinf.2014.06.011 |
| Language: | English |
| Additional information: | Crown copyright © 2014 Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/) |
| Keywords: | Bacterial meningitis; Streptococcus pneumoniae; Bacterial load; Cerebrospinal fluid; Cytokine response; Mortality; Africa |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1529816 |
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