Meppelink, AM;
Little, S;
Oswal, A;
Erro, R;
Kilner, J;
Tijssen, MAJ;
Brown, P;
... Edwards, M; + view all
(2016)
Event related desynchronisation predicts functional propriospinal myoclonus.
Parkinsonism & Related Disorders
, 31
pp. 116-118.
10.1016/j.parkreldis.2016.07.010.
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Abstract
Objective Recent diagnostic criteria for functional movement disorders have proposed a “laboratory supported” level of diagnostic certainty where the clinical diagnosis is supported by a positive test. For functional myoclonus the Bereitschaftspotential (BP) is generally accepted as a positive laboratory test. We hypothesised that a different EEG measure, event-related desynchronisation (ERD), might be more effective. Methods We analysed 20 patients with functional propriospinal myoclonus (fPSM) and 9 controls with organic myoclonus and performed back-averaging for BPs plus time-frequency decomposition to assess ERD and calculated sensitivity and specificity for both techniques. Results The BP was present in only 25% of patients with fPSM while the majority showed a significant ERD (mean 38 Hz; sensitivity 65%). ERD was significant at the group level (p < 0.001), but not the BP (p > 0.05). Both BP and ERD were absent in our control group. Conclusion ERD in high-beta may be a useful new test for positive diagnosis of functional myoclonus.
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