Dzieciol, AM;
Bachevalier, J;
Saleem, KS;
Gadian, DG;
Saunders, R;
Chong, WK;
Banks, T;
... Vargha-Khadem, F; + view all
(2017)
Hippocampal and diencephalic pathology in developmental amnesia.
Cortex
, 86
pp. 33-44.
10.1016/j.cortex.2016.09.016.
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Abstract
Developmental amnesia (DA) is a selective episodic memory disorder associated with hypoxia-induced bilateral hippocampal atrophy of early onset. Despite the systemic impact of hypoxia-ischaemia, the resulting brain damage was previously reported to be largely limited to the hippocampus. However, the thalamus and the mammillary bodies are parts of the hippocampal-diencephalic network and are therefore also at risk of injury following hypoxic-ischaemic events. Here, we report a neuroimaging investigation of diencephalic damage in a group of 18 patients with DA (age range 11-35 years), and an equal number of controls. Importantly, we uncovered a marked degree of atrophy in the mammillary bodies in two thirds of our patients. In addition, as a group, patients had mildly reduced thalamic volumes. The size of the anterior-mid thalamic (AMT) segment was correlated with patients' visual memory performance. Thus, in addition to the hippocampus, the diencephalic structures also appear to play a role in the patients' memory deficit.
| Type: | Article |
|---|---|
| Title: | Hippocampal and diencephalic pathology in developmental amnesia. |
| Location: | Italy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cortex.2016.09.016 |
| Publisher version: | http://dx.doi.org/10.1016/j.cortex.2016.09.016 |
| Language: | English |
| Additional information: | © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Hippocampus, Hypoxia-ischaemia, Mammillary bodies, Memory, Thalamus |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1529542 |
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