Messager, L;
Burns, JR;
Kim, J;
Cecchin, D;
Hindley, J;
Pyne, ALB;
Gaitzsch, J;
... Howorka, S; + view all
(2016)
Biomimetic Hybrid Nanocontainers with Selective Permeability.
Angewandte Chemie - International Edition
, 55
(37)
pp. 11106-11109.
10.1002/anie.201604677.
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Messager Biomimetic Hybrid Nanocontainers with Selective Permeability Angewandte Chemie International ed.pdf - Published Version Download (2MB) | Preview |
Abstract
Chemistry plays a crucial role in creating synthetic analogues of biomacromolecular structures. Of particular scientific and technological interest are biomimetic vesicles that are inspired by natural membrane compartments and organelles but avoid their drawbacks, such as membrane instability and limited control over cargo transport across the boundaries. In this study, completely synthetic vesicles were developed from stable polymeric walls and easy-to-engineer membrane DNA nanopores. The hybrid nanocontainers feature selective permeability and permit the transport of organic molecules of 1.5 nm size. Larger enzymes (ca. 5 nm) can be encapsulated and retained within the vesicles yet remain catalytically active. The hybrid structures constitute a new type of enzymatic nanoreactor. The high tunability of the polymeric vesicles and DNA pores will be key in tailoring the nanocontainers for applications in drug delivery, bioimaging, biocatalysis, and cell mimicry.
| Type: | Article |
|---|---|
| Title: | Biomimetic Hybrid Nanocontainers with Selective Permeability |
| Location: | Seville, SPAIN |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/anie.201604677 |
| Publisher version: | http://dx.doi.org/10.1002/anie.201604677 |
| Language: | English |
| Additional information: | Copyright © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co KGaA. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | DNA; enzymes; membranes; nanopores; nanotechnology; polymersomes |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1528760 |
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