Khan, KN;
Mahroo, OA;
Islam, F;
Webster, AR;
Moore, AT;
Michaelides, M;
(2017)
Functional and Anatomical Outcomes of Choroidal Neovascularization Complicating Best1-related Retinopathy.
Retina
, 37
(7)
pp. 1360-1370.
10.1097/IAE.0000000000001357.
Preview |
Text
michaelides_et_al_accepted_manuscript.pdf Download (911kB) | Preview |
Abstract
PURPOSE: To describe the presenting features and functional outcomes in a series of patients with choroidal neovascular membrane complicating BEST1-related retinopathy (Best disease and autosomal recessive bestrophinopathy). METHODS: Retrospective review of consecutive cases at a tertiary care eye hospital. Patients were identified retrospectively over an 11-year period. Records were reviewed to extract demographic as well as functional and anatomical outcome data. RESULTS: Fourteen eyes of 12 patients were identified (11 Best disease and 1 autosomal recessive bestrophinopathy). Median follow-up was 2.8 years (range 0.8-6). The median age at choroidal neovascular membrane discovery was 15.5 years (range 6-72). Choroidal neovascular membranes were active early in the disease course before vitelliruption. Seven eyes were treated with intravitreal bevacizumab, 7 eyes were monitored by observation alone. On average, patients required a single treatment (median = 1, range 1-10). The median gain in visual acuity was greater in the treated versus the observed group-0.46 versus 0.17 decimalized units of Snellen acuity, respectively (P < 0.05 Mann-Whitney U test). Although a significant reduction in central macular thickness was evident in both groups, 150 μm (treated) and 104 μm (observed), active treatment was not associated with greater thinning than observation (P > 0.05 Mann-Whitney U test). CONCLUSION: There is a high rate of spontaneous recovery of BEST1-related choroidal neovascular membrane, and overall the authors observed a gain in visual acuity associated with a reduction in central macular thickness. Active treatment, here with intravitreal bevacizumab, is associated with better functional outcomes than observation alone.
| Type: | Article |
|---|---|
| Title: | Functional and Anatomical Outcomes of Choroidal Neovascularization Complicating Best1-related Retinopathy |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/IAE.0000000000001357 |
| Publisher version: | http://doi.org/10.1097/IAE.0000000000001357 |
| Language: | English |
| Additional information: | Copyright © by Ophthalmic Communications Society, Inc. Unauthorized reproduction of this article is prohibited. This is a non-final version of an article published in final form in Khan, KN; Mahroo, OA; Islam, F; Webster, AR; Moore, AT; Michaelides, M; (2016) Functional and Anatomical Outcomes of Choroidal Neovascularization Complicating Best1-related Retinopathy. Retina 10.1097/IAE.0000000000001357. |
| Keywords: | Autosomal recessive best retinopathy, best-related retinopathy, choroidal neovascularization, retina, retinal dystrophy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1527362 |
Archive Staff Only
 |
View Item |
