Littooij, AS;
Sebire, NJ;
Olsen, ØE;
(2017)
Whole-tumor apparent diffusion coefficient measurements in nephroblastoma: Can it identify blastemal predominance?
Journal of Magnetic Resonance Imaging
, 45
(5)
pp. 1316-1324.
10.1002/jmri.25506.
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Abstract
PURPOSE: To explore the potential relation between whole-tumor apparent diffusion coefficient (ADC) parameters in viable parts of tumor and histopathological findings in nephroblastoma. MATERIALS AND METHODS: Children (n = 52) with histopathologically proven nephroblastoma underwent diffusion-weighted magnetic resonance imaging (MRI) (1.5T) before preoperative chemotherapy. Of these, 25 underwent an additional MRI after preoperative chemotherapy, shortly before resection. An experienced reader performed the whole-tumor ADC measurements of all lesions, excluding nonenhancing areas. An experienced pathologist reviewed the postoperative specimens according to standard SIOP guidelines. Potential associations between ADC parameters and proportions of histological subtypes were assessed with Pearson's or Spearman's rank correlation coefficient depending on whether the parameters tested were normally distributed. In case the Mann-Whitney U-test revealed significantly different ADC values in a subtype tumor, this ADC parameter was used to derive a receiver operating characteristic (ROC) curve. RESULTS: The 25(th) percentile ADC at presentation was the best ADC metric correlated with proportion of blastema (Pearson's r = -0.303, P = 0.026). ADC after preoperative treatment showed moderate correlation with proportion stromal subtype at histopathology (r = 0.579, P = 0.002). By ROC analysis, the optimal threshold of median ADC for detecting stromal subtype was 1.362 × 10(-3) mm(2) /s with sensitivity and specificity of 100% (95% confidence interval [CI] 0.65-1.00) and 78.9% (95% CI 0.57-0.92), respectively. CONCLUSION: ADC markers in nephroblastoma are related to stromal subtype histopathology; however, identification of blastemal predominant tumors using whole-tumor ADC measurements is probably not feasible. Level of Evidence 3 J. Magn. Reson. Imaging 2016;00:000-000.
| Type: | Article |
|---|---|
| Title: | Whole-tumor apparent diffusion coefficient measurements in nephroblastoma: Can it identify blastemal predominance? |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/jmri.25506 |
| Publisher version: | http://dx.doi.org/10.1002/jmri.25506 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Littooij, AS; Sebire, NJ; Olsen, ØE; (2016) Whole-tumor apparent diffusion coefficient measurements in nephroblastoma: Can it identify blastemal predominance? Journal of Magnetic Resonance Imaging, which has been published in final form at: http://dx.doi.org/10.1002/jmri.25506. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms). |
| Keywords: | children, diffusion-weighted imaging, magnetic resonance imaging, nephroblastoma, whole-tumor apparent diffusion coefficient |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1524829 |
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