Wall, IB;
Toledo, GS;
Jat, PS;
(2016)
Recent advances in conditional cell immortalization technology.
Cell & Gene Therapy Insights
, 2
(3)
pp. 391-396.
10.18609/cgti.2016.041.
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Abstract
Gene-modified cell therapies are transforming medicine. Over the last 18 months, notable clinical successes using antigen-targeting cellular immunotherapies have been achieved. However, another kind of gene modification has significant potential for the cell therapy industry. The development of fully controllable transgenes has enabled the creation of conditionally immortalized cells that can be expanded to clinical quantities in a stable and consistent fashion, yet can be returned to a normal, non-dividing state for therapeutic delivery to the patient. In this article, we discuss some of the key technologies that have been used to create conditionally immortalized cells for clinical development.
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