Klejevskaja, B;
Pyne, ALB;
Reynolds, M;
Shivalingam, A;
Thorogate, R;
Hoogenboom, BW;
Ying, L;
(2016)
Studies of G-quadruplexes formed within self-assembled DNA mini-circles.
Chemical Communications
, 52
(84)
pp. 12454-12457.
10.1039/c6cc07110d.
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Abstract
We have developed self-assembled DNA mini-circles that contain a G-quadruplex-forming sequence from the c-Myc oncogene promoter and demonstrate by FRET that the G-quadruplex unfolding kinetics are 10-fold slower than for the simpler 24-mer G-quadruplex that is commonly used for FRET experiments.
| Type: | Article |
|---|---|
| Title: | Studies of G-quadruplexes formed within self-assembled DNA mini-circles |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c6cc07110d |
| Publisher version: | http://dx.doi.org/10.1039/c6cc07110d |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, TELOMERIC G-QUADRUPLEX, SMALL-MOLECULE, FUNCTIONALIZATION, TRANSCRIPTION, MINICIRCLES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1521444 |
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