Bear, JC;
Patrick, PS;
Casson, A;
Southern, P;
Lin, F-Y;
Powell, MJ;
Pankhurst, QA;
... Mayes, AG; + view all
(2016)
Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection.
Scientific Reports
, 6
(34271)
10.1038/srep34271.
![[thumbnail of Pankhurst_2016 SciRep Controlled release in GI tract.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
Pankhurst_2016 SciRep Controlled release in GI tract.pdf - Published Version Download (1MB) |
Abstract
Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug- delivery vehicle must experience before it releases it’s drug payload. Effective targeted drug delivery systems often rely on external stimuli to effect release, therefore knowing the exact location of the capsule and when to apply an external stimulus is paramount. We present a drug delivery system for the GI tract based on coating standard gelatin drug capsules with a model eicosane- superparamagnetic iron oxide nanoparticle composite coating, which is activated using magnetic hyperthermia as an on-demand release mechanism to heat and melt the coating. We also show that the capsules can be readily detected via rapid X-ray computed tomography (CT) and magnetic resonance imaging (MRI), vital for progressing such a system towards clinical applications. This also offers the opportunity to image the dispersion of the drug payload post release. These imaging techniques also influenced capsule content and design and the delivered dosage form. The ability to easily change design demonstrates the versatility of this system, a vital advantage for modern, patient-specific medicine.
| Type: | Article |
|---|---|
| Title: | Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/srep34271 |
| Publisher version: | http://dx.doi.org/10.1038/srep34271 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ © The Author(s) 2016 |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, Delivery-Systems, Superparamagnetic Nanoparticles, Triggered Release, Cancer-Therapy, Iron-Oxides, On-Demand, Laxatives, Nanotechnology, Ultrasound, Carriers |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Education UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1519886 |
Archive Staff Only
 |
View Item |
