Cockcroft, JK;
Buanz, ABM;
Ntantou, A;
Price, LS;
Tocher, DA;
Vickers, M;
Lancaster, RW;
(2016)
Polymorphism in 2-Chlorobenzamide: Run of the Mill or Not?
Crystal Growth and Design
, 16
(11)
pp. 6144-6147.
10.1021/acs.cgd.6b00973.
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Abstract
Structures of two very similar polymorphic forms of 2-chlorobenzamide have been obtained at low temperature. The metastable α-form is very susceptible to grinding, a property not initially realized considering the polymorphs have been reported in the literature for many years. Systematic milling studies have been carried out in a search for other polymorphic forms and to assess the rate of any polymorphic change(s). No new polymorphs were found, though a computational search for low energy structures suggested a complex crystal-energy landscape. An experimental polymorph screen was also carried out.
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