Pinotsis, DA; Perry, G; Litvak, V; Singh, KD; Friston, KJ; (2016) Intersubject variability and induced gamma in the visual cortex: DCM with empirical Bayes and neural fields. Human Brain Mapping 10.1002/hbm.23331.

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Abstract

This article describes the first application of a generic (empirical) Bayesian analysis of between-subject effects in the dynamic causal modeling (DCM) of electrophysiological (MEG) data. It shows that (i) non-invasive (MEG) data can be used to characterize subject-specific differences in cortical microcircuitry and (ii) presents a validation of DCM with neural fields that exploits intersubject variability in gamma oscillations. We find that intersubject variability in visually induced gamma responses reflects changes in the excitation-inhibition balance in a canonical cortical circuit. Crucially, this variability can be explained by subject-specific differences in intrinsic connections to and from inhibitory interneurons that form a pyramidal-interneuron gamma network. Our approach uses Bayesian model reduction to evaluate the evidence for (large sets of) nested models-and optimize the corresponding connectivity estimates at the within and between-subject level. We also consider Bayesian cross-validation to obtain predictive estimates for gamma-response phenotypes, using a leave-one-out procedure. Hum Brain Mapp, 2016. © The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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