Daniel, MC;
O’Gallagher, M;
Hingorani, M;
Dahlmann-Noor, A;
Tuft, S;
(2016)
Challenges in the management of pediatric blepharokeratoconjunctivis / ocular rosacea.
Expert Review of Ophthalmology
, 11
(4)
pp. 299-309.
10.1080/17469899.2016.1209408.
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Abstract
Introduction: Childhood blepharokeratoconjunctivitis is a common lid margin inflammation with secondary ocular surface disease. Its etiology is unclear and there are no randomized controlled trials to support the superiority of any treatment option. / Areas covered: We searched the following databases; Cochrane Central Register of Controlled Trials, Ovid MEDLINE and affiliated Ovid databases, EMBASE, the ISRCTN registry, Clinical- Trials.gov and the World Health Organization International Clinical Trials Registry Platform. Due to the paucity of pediatric data we also considered information from articles focused on adults. / Expert commentary: Treatment is based on the assumption that the mechanisms of BKC and rosacea keratitis are the same: meibomian gland dysfunction, bacterial colonisation of the lid margin, delayed type hypersensitivity, Demodex folliculorum, genetic predisposition and Toll-like receptors inducing release of pro-inflammatory cytokines. Generally accepted grading scales are needed. Randomized clinical trials are needed to evaluate treatment options. The effects of antibiotics, immunomodulators, osmoprotectants and essential fatty acids need further investigation.
| Type: | Article |
|---|---|
| Title: | Challenges in the management of pediatric blepharokeratoconjunctivis / ocular rosacea |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/17469899.2016.1209408 |
| Publisher version: | http://dx.doi.org/10.1080/17469899.2016.1209408 |
| Language: | English |
| Additional information: | Copyright © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
| Keywords: | Blepharokeratoconjunctivitis, blepharoconjunctivitis, blepharitis, dry eye disease, meibomian gland disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1514588 |
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