Simulundu, E;
Mweene, AS;
Changula, K;
Monze, M;
Chizema, E;
Mwaba, P;
Takada, A;
... Bates, M; + view all
(2016)
Lujo viral hemorrhagic fever: considering diagnostic capacity and preparedness in the wake of recent Ebola and Zika virus outbreaks.
Reviews in Medical Virology
, 26
(6)
pp. 446-454.
10.1002/rmv.1903.
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Abstract
Lujo virus is a novel Old World arenavirus identified in Southern Africa in 2008 as the cause of a viral hemorrhagic fever (VHF) characterized by nosocomial transmission with a high case fatality rate of 80% (4/5 cases). Whereas this outbreak was limited, the unprecedented Ebola virus disease outbreak in West Africa, and recent Zika virus disease epidemic in the Americas, has brought into acute focus the need for preparedness to respond to rare but potentially highly pathogenic outbreaks of zoonotic or arthropod-borne viral infections. A key determinant for effective control of a VHF outbreak is the time between primary infection and diagnosis of the index case. Here, we review the Lujo VHF outbreak of 2008 and discuss how preparatory measures with respect to developing diagnostic capacity might be effectively embedded into existing national disease control networks, such as those for human immunodeficiency virus, tuberculosis, and malaria.
| Type: | Article |
|---|---|
| Title: | Lujo viral hemorrhagic fever: considering diagnostic capacity and preparedness in the wake of recent Ebola and Zika virus outbreaks |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/rmv.1903 |
| Publisher version: | http://dx.doi.org/10.1002/rmv.1903 |
| Language: | English |
| Additional information: | Copyright © 2016 John Wiley & Sons, Ltd. This is the peer reviewed version of the following article:Simulundu, E., Mweene, A. S., Changula, K., Monze, M., Chizema, E., Mwaba, P., Takada, A., Ippolito, G., Kasolo, F., Zumla, A., and Bates, M. (2016) Lujo viral hemorrhagic fever: considering diagnostic capacity and preparedness in the wake of recent Ebola and Zika virus outbreaks. Rev. Med. Virol., 26: 446–454., which has been published in final form at http://dx.doi.org/10.1002/rmv.1903. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Keywords: | Arenaviridae, Ebola virus disease, Lujo virus, Mammarenavirus, Zika virus, diagnostic capacity, lessons, preparedness, viral hemorrhagic fever |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1514555 |
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