Zimmer, F;
(2016)
Gene dosage and the evolution of gene expression.
Doctoral thesis , UCL (University College London).
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Abstract
The duplication and loss of genes, chromosomes and whole genomes has had a major impact on the evolution of most organisms. Changes in gene copy number, called gene dosage, may influence the resulting level of gene product through changes in gene expression. These gene expression changes can be detrimental, resulting in compensation and buffering mechanisms, or beneficial, when selection favours increased gene dosage. Understanding how changes in gene dose can influence the evolution of gene expression within and between species is an important task in evolutionary biology. This thesis combines studies of gene, protein domain, and genome duplications with gene expression data from a range of bird species to understand the evolutionary consequences of gene dosage changes. In addition to gene duplication and loss events, the genomic location of genes can subject loci to different evolutionary pressures. Genes present on sex chromosomes or the mitochondria are inherited unequally between males and females, potentially causing sexual conflict over expression. This thesis investigates if inter-genomic conflict could drive gene movement on and off the sex chromosomes using a comparative genomics approach.
| Type: | Thesis (Doctoral) |
|---|---|
| Title: | Gene dosage and the evolution of gene expression |
| Event: | University College London |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Third party copyright material has been removed from ethesis. |
| UCL classification: | UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1514515 |
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