Saleem, I;
Petkar, K;
Somavarapu, S;
(2017)
Rationale for Pulmonary Vaccine Delivery: Formulation and Device Considerations.
In:
Micro- and Nanotechnology in Vaccine Development.
(pp. 357-371).
Elsevier
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Abstract
Delivery of vaccines via the pulmonary route has been shown to induce mucosal and systemic immunity. In addition, these important disease prevention and control agents can be formulated and administered as dry powders, which can overcome the cold-chain and medical personnel requirements. Furthermore, vaccines can be formulated within particulate delivery systems, allowing for enhanced interaction, targeting, and uptake with antigen presenting cells and initiating an enhanced immune response. This chapter outlines the rationale and challenges of targeting the lung antigen presenting cells to initiate an immune response, micro- and nanoparticulate delivery systems with focus on engineering dry powders for inhalation, and pulmonary devices for administration. In addition, some recent case studies are presented, indicating the rationale for pulmonary vaccine delivery compared with other routes of delivery and the importance of device design in pulmonary vaccine administration.
| Type: | Book chapter |
|---|---|
| Title: | Rationale for Pulmonary Vaccine Delivery: Formulation and Device Considerations |
| ISBN-13: | 9780323399814 |
| DOI: | 10.1016/B978-0-323-39981-4.00019-1 |
| Publisher version: | https://doi.org/10.1016/B978-0-323-39981-4.00019-1 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1514460 |
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