Miah, S;
Ahmed, HU;
Freeman, A;
Emberton, M;
(2016)
Does true Gleason pattern 3 merit its cancer descriptor?
Nature Reviews Urology
, 13
(9)
pp. 541-548.
10.1038/nrurol.2016.141.
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Abstract
Nearly five decades following its conception, the Gleason grading system remains a cornerstone in the prognostication and management of patients with prostate cancer. In the past few years, a debate has been growing whether Gleason score 3 + 3 = 6 prostate cancer is a clinically significant disease. Clinical, molecular and genetic research is addressing the question whether well characterized Gleason score 3 + 3 = 6 disease has the ability to affect the morbidity and quality of life of an individual in whom it is diagnosed. The consequences of treatment of Gleason score 3 + 3 = 6 disease are considerable; few men get through their treatments without sustaining some harm. Further modification of the classification of prostate cancer and dropping the label cancer for Gleason score 3 + 3 = 6 disease might be warranted.
| Type: | Article |
|---|---|
| Title: | Does true Gleason pattern 3 merit its cancer descriptor? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nrurol.2016.141 |
| Publisher version: | http://doi.org/10.1038/nrurol.2016.141 |
| Language: | English |
| Additional information: | © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, LOCALIZED PROSTATE-CANCER, PAPILLARY UROTHELIAL NEOPLASMS, 2005 INTERNATIONAL-SOCIETY, POPULATION-BASED COHORT, RADICAL PROSTATECTOMY, NEEDLE-BIOPSY, ACTIVE SURVEILLANCE, INTEROBSERVER REPRODUCIBILITY, GRADING SYSTEM, CLONAL ORIGIN, Diagnosis, Diagnostic markers, Prognosis, Prostate cancer |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1513331 |
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