Yong, K;
Delforge, M;
Driessen, C;
Fink, L;
Flinois, A;
Gonzalez-McQuire, S;
Karlin, L;
... Cavo, M; + view all
(2016)
Multiple myeloma: patient outcomes in real-world practice.
British Journal of Haematology
, 175
(2)
pp. 252-264.
10.1111/bjh.14213.
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Abstract
With increasing number of therapies available for the treatment of multiple myeloma, it is timely to examine the course of patients’ journeys. We investigated patient characteristics, treatment durations and outcomes, and symptom burden across the treatment pathway in Belgium, France, Germany, Italy, Spain, Switzerland and the UK. In total, 435 physicians retrospectively reviewed 4997 patient charts. Profiles of patients diagnosed with multiple myeloma during the last 12 months were similar across countries; bone pain was the most common presentation. Median duration of firstline therapy was 6 months, followed by a median treatment-free interval of 10 months; both these decreased with increasing lines of therapy, as did time to progression. Depth of response, as assessed by the treating physician, also decreased with each additional line of therapy: 74% of patients achieved at least a very good partial response at first line, compared with only 11% at fifth line. Deeper responses were associated with longer time to progression, although these were physician-judged. Toxicities and comorbidities increased with later treatment lines, and were more likely to have led to discontinuation of treatment. These real-world data provide an insight into patient outcomes and treatment decisions being made in clinical practice.
| Type: | Article |
|---|---|
| Title: | Multiple myeloma: patient outcomes in real-world practice |
| Location: | Vienna, AUSTRIA |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bjh.14213 |
| Publisher version: | http://dx.doi.org/10.1111/bjh.14213 |
| Language: | English |
| Additional information: | Copyright © 2016 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | Multiple myeloma, real-world practice, patient chart review,duration of therapy, depth of response. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1510612 |
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