Mercuri, E;
Coratti, G;
Messina, S;
Ricotti, V;
Baranello, G;
D'Amico, A;
Pera, MC;
... Pane, M; + view all
(2016)
Revised North Star Ambulatory Assessment for Young Boys with Duchenne Muscular Dystrophy.
PLoS ONE
, 11
(8)
, Article e0160195. 10.1371/journal.pone.0160195.
Preview |
Text
Muntoni_revised north star ambulatory assessment_.PDF - Published Version Download (346kB) | Preview |
Abstract
The advent of therapeutic approaches for Duchenne muscular dystrophy (DMD) has highlighted the need to identify reliable outcome measures for young boys with DMD. The aim of this study was to develop a revised version of the North Star Ambulatory Assessment (NSAA) suitable for boys between the age of 3 and 5 years by identifying age appropriate items and revising the scoring system accordingly. Using the scale in 171 controls between the age of 2.9 and 4.8 years, we identified items that were appropriate at different age points. An item was defined as age appropriate if it was completed, achieving a full score, by at least 85% of the typically developing boys at that age. At 3 years (±3months) there were only 8 items that were age appropriate, at 3 years and 6 months there were 13 items while by the age of 4 years all 17 items were appropriate. A revised version of the scale was developed with items ordered according to the age when they could be reliably performed. The application of the revised version of the scale to data collected in young DMD boys showed that very few of the DMD boys were able to complete with a full score all the age appropriate items. In conclusion, our study suggests that a revised version of the NSAA can be used in boys from the age of 3 years to obtain information on how young DMD boys acquire new abilities and how this correlates with their peers.
| Type: | Article |
|---|---|
| Title: | Revised North Star Ambulatory Assessment for Young Boys with Duchenne Muscular Dystrophy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0160195 |
| Publisher version: | http://doi.org/10.1371/journal.pone.0160195 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, 6-MINUTE WALK TEST, CHILDREN, MOTOR |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1510124 |
Archive Staff Only
 |
View Item |
