Linsmeier, I;
Banerjee, S;
Oakes, PW;
Jung, W;
Kim, T;
Murrell, MP;
(2016)
Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility.
Nature Communications
, 7
, Article 12615. 10.1038/ncomms12615.
Preview |
Text
Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility.pdf - Published Version Download (7MB) | Preview |
Abstract
While the molecular interactions between individual myosin motors and F-actin are well established, the relationship between F-actin organization and actomyosin forces remains poorly understood. Here we explore the accumulation of myosin-induced stresses within a two-dimensional biomimetic model of the disordered actomyosin cytoskeleton, where myosin activity is controlled spatiotemporally using light. By controlling the geometry and the duration of myosin activation, we show that contraction of disordered actin networks is highly cooperative, telescopic with the activation size, and capable of generating non-uniform patterns of mechanical stress. We quantitatively reproduce these collective biomimetic properties using an isotropic active gel model of the actomyosin cytoskeleton, and explore the physical origins of telescopic contractility in disordered networks using agent-based simulations.
| Type: | Article |
|---|---|
| Title: | Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/ncomms12615 |
| Publisher version: | http://doi.org/10.1038/ncomms12615 |
| Language: | English |
| Additional information: | Copyright © 2016 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Stress Fibers, Focal Adhesions, Adherent Cells, Active Gels, Cytoskeletal Dynamics, Traction Stresses, Filament Length, Myosin-ii, Mechanics, Substrate |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1508585 |
Archive Staff Only
 |
View Item |
