Jette, N;
Sander, JW;
Keezer, MR;
(2016)
Surgical treatment for epilepsy: the potential gap between evidence and practice.
The Lancet Neurology
, 15
(9)
pp. 982-994.
10.1016/S1474-4422(16)30127-2.
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Abstract
Findings from randomised controlled trials, along with more than 100 case series and observational studies, support the efficacy and safety of resective surgery and, more recently, non-resective surgical interventions for the treatment of drug-resistant epilepsy in appropriately selected individuals. There is an argument that epilepsy surgery remains underused, but the evidence to support this assertion is at times unclear. Results from longitudinal studies show a stagnant or declining rate of epilepsy surgery over time, despite the evidence and guidelines supporting its use. Some suggest that this stagnation is due to a decreasing pool of eligible surgical candidates, whereas others emphasise the numerous barriers to epilepsy surgery. Strategies exist to increase access to surgery and to improve communication about the effectiveness of this potentially life-changing procedure. Further investigation into the nature and causes of the presumed underuse of epilepsy surgery and the elaboration of strategies to address this treatment gap are necessary and pressing.
| Type: | Article |
|---|---|
| Title: | Surgical treatment for epilepsy: the potential gap between evidence and practice |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/S1474-4422(16)30127-2 |
| Publisher version: | http://dx.doi.org/10.1016/S1474-4422(16)30127-2 |
| Language: | English |
| Additional information: | Copyright © 2016. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Science and Technology, Life Sciences and Biomedicine, Clinical Neurology, Neurosciences and Neurology, Temporal-lobe Epilepsy, Vagus Nerve-stimulation, Randomized Controlled-trial, Drug-resistant Epilepsy, Extratemporal Nonlesional Epilepsy, Prospective Clinical-trial, Health-care Costs, Quality-of-life, United-states, Refractory Epilepsy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1508172 |
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