Palachanis, D;
Szabó, A;
Merks, RMH;
(2015)
Particle-based simulation of ellipse-shaped particle aggregation as a model for vascular network formation.
Computational Particle Mechanics
, 2
(4)
pp. 371-379.
10.1007/s40571-015-0064-5.
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Abstract
Computational modeling is helpful for elucidating the cellular mechanisms driving biological morphogenesis. Previous simulation studies of blood vessel growth based on the cellular Potts model proposed that elongated, adhesive or mutually attractive endothelial cells suffice for the formation of blood vessel sprouts and vascular networks. Because each mathematical representation of a model introduces potential artifacts, it is important that model results are reproduced using alternative modeling paradigms. Here, we present a lattice-free, particle-based simulation of the cell elongation model of vasculogenesis. The new, particle-based simulations confirm the results obtained from the previous cellular Potts simulations. Furthermore, our current findings suggest that the emergence of order is possible with the application of a high enough attractive force or, alternatively, a longer attraction radius. The methodology will be applicable to a range of problems in morphogenesis and noisy particle aggregation in which cell shape is a key determining factor.
| Type: | Article |
|---|---|
| Title: | Particle-based simulation of ellipse-shaped particle aggregation as a model for vascular network formation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s40571-015-0064-5 |
| Publisher version: | http://doi.org/10.1007/s40571-015-0064-5 |
| Language: | English |
| Additional information: | Copyright © 2015 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | Vasculogenesis; Cell-based model; Cell elongation; Morphogenesis; Alignment order |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1508162 |
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